Lyra-Junior's Page

I. EDUCATION

2018 - 2019: Postdoctorate. Universidade Federal do Espírito Santo, UFES, Brasil. Grantee of: Fundação de Amparo à Pesquisa do Espírito Santo ,FAPES/ES ,Brasil . Major Area: Biological Sciences. Major Area: Health Sciences / Área: Medicine / Subarea: Cancerologia.

2014 - 2018: Ph.D. in Biotecnologia. Rede Nordeste de Biotecnologia, RENORBIO, Brasil. with collaborative period in H. Lee Moffitt Cancer Center and Research Institute(Advisor:Álvaro N. A. Monteiro ). Year of degree: 2018. Advisor: Leticia Batista de Azevedo Rangel. Grantee of: Fundação de Amparo à Pesquisa do Espírito Santo ,FAPES/ES ,Brasil . Keywords: SNPs; GWAS; Functional Analysis. Major Area: Health Sciences. Major Area: Biological Sciences / Area: Genetics / Subarea: Human genetic

2011 - 2013: Master´s in Biotecnologia. Universidade Federal do Espírito Santo, UFES, Brasil. Year of degree: 2013. Advisor: Leticia Batista Azevedo Rangel. Grantee of: Fundação de Amparo à Pesquisa do Espírito Santo ,FAPES/ES ,Brazil .

2007 - 2011: Bachelor of Pharmacy. Escola Superior de Ciências da Santa Casa de Misericórdia de Vitória, EMESCAM, Brazil. Advisor: Débora Dummer Meira.

II. ACADEMIC APPOINTMENTS AND EMPLOYMENT

2020 - present: Faculdade de Ensino e Meio Ambiente (FAEMA) Professor and coordinator of the bachelor pharmacy course

2012 - 2014: Professor, Department of Pharmacy, University of Espírito Santo, Vitória, Espírito Santo, Brazil.

2013 - 2014: Professor, Department of Pharmacy, College of Philosophy, Science and Letters of Alegre, Alegre, ES, Brazil.

III. PUBLICATIONS

LYRA-JR, PCM et al. Integration of functional assay data results provides strong evidence for classification of hundreds of BRCA1 variants of uncertain significance. GENETICS IN MEDICINE. 2020.

LYRA-JR, PCM et al. Functional Landscape of Common Variants Associated with Susceptibility to Epithelial Ovarian Cancer. CURRENT EPIDEMIOLOGY REPORTS. 2020.

GUSEV, ALEXANDER ; LAWRENSON, KATE ; LIN, XIANZHI ; LYRA-JR, PCM et al. A transcriptome-wide association study of high-grade serous epithelial ovarian cancer identifies new susceptibility genes and splice variants. NATURE GENETICS, v. 51, p. 815-823, 2019.

BUCKLEY, MELISSA A. ; WOODS, NICHOLAS T. ; TYRER, JONATHAN P ; MENDOZA-FANDIÑO, GUSTAVO ; LAWRENSON, KATE ; HAZELETT, DENNIS J. ; NAJAFABADI, HAMED S ; GJYSHI, ANXHELA ; CARVALHO, RENATO S. ; LYRA-JR, PCM et al. Functional analysis and fine mapping of the 9p22.2 ovarian cancer susceptibility locus. CANCER RESEARCH, v. 3864, p. canres.3864.2017, 2018.

PHELAN, CATHERINE M ; KUCHENBAECKER, KAROLINE B ; TYRER, JONATHAN P ; KAR, SIDDHARTHA P ; LAWRENSON, KATE ; WINHAM, STACEY J ; DENNIS, JOE ; PIRIE, AILITH ; RIGGAN, MARJORIE J ; CHORNOKUR, GANNA ; EARP, MADALENE A ; LYRA-JR, PCM et al. Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer. NATURE GENETICS, v. 1, p. 1, 2017.

B. A. Rangel, Leticia (Org.) ; Kirubamani, Hephzibah (Org.) ; Victor Silva, Ian (Org.) ; Cilas Morais Lyra Junior, Paulo (Org.). 1ed. IntechOpen, 2020.DOI: 10.5772/intechopen.77810

Lyra Junior, P. C. M.; Tessarollo, N.; Guimaraes, I.; Henriques, T. B.; Dos Santos, Diandra Z.; Souza, M. L. M.; Marques, V. H.; De Oliveira, Laura F.R.L.; Vaz, K.; Silva, Iv; Rangel, Lba; Branco, A. T. 1 Ed. Intech, 2017, V. 1, P. 99-118.

Guimarães, Isabella S.; Tessarollo, Nayara G.; Lyra-Júnior, Paulo C.M.; dos Santos, Diandra Z.; Zampier, Roger C.; de Oliveira, Laura F.R.L.; Siqueira, Krislayne V.; Silva, Ian V.; Rangel, Leticia B.A. 1 ed. InTech, 2015.

Ladislau, Taciane; P, Klesia; D, Renata; S Guimares, Isabella; F, Sarah; CM, Paulo; C, Iuri; BA, Leticia; L, Alice. 2 ed. InTech, 2013, v. 1, p. 37-63.

Santos Guimares, Isabella dos; Dalmaschio, Renata; Herlinger, Alice Laschuk; Pirola, Klesia; Ladislau, Taciane; Valado, Iuri Cordeiro; Lyra Junior, Paulo Cilas Morais; Fernandes Teixeira, Sarah; Modesto, Gustavo; dos Santos, Diandra Zipinotti; Rangel, Karina; Azevedo Rangel, Leticia Batista. 01 ed. : InTech, 2013, v. 1, p. 03-35.

Madeira, K.; Guimaraes, I.; Daltoe, R.; Herlinger, A.; Ladislau, T.; Valadao, I.; Lyra Junior, P. C. M.; Teixeira, S.; Silva, Iv; Rangel, Lba . 1 Ed. : Nova Science Publishers, Inc., 2012, V. 1, P. 89-113.

Tessarollo, Nayara G.; SILVA, IV; Guimarães, Isabella S.; dos Santos, Diandra Z.; Henriques, T. B.; de Oliveira, Laura F.R.L.; Siqueira, Krislayne V.; Souza, M. L. M. ; Lyra-Júnior, Paulo C.M. Identification of phosphodiesterase 7A (PDE7A) as a therapeutic target to treat HGSOC. 2017, Brazil. Utility model patent. Register number: BR1020170080552, title: "Identificação de fosfodiesterase 7A (PDE7A) como alvo terapêutico contra o câncer de ovário seroso de alto grau" , Registered at: INPI - Instituto Nacional da Propriedade Industrial, Responsible: Letícia Batista Azevedo Rangel, Date of deposit: 19/04/2017.

Amorim, G. M.; Valadao, I.; Teixeira, S.; Santos Guimares, Isabella Dos; Lyra Junior, P. C. M.; Rodrigues, V. C; Demuth, K. R.; Madeira, K.; Borges, W. S; Greco, S.; Rangel, Leticia B.A. , 2013, Rio De Janeiro. Xxxviii Congress Of The Brazilian Society Of Immunology / 11th World Congress On Inflamation, 2013.

Ladislau, T.; Silva, D.; Madeira, K.; Daltoe, R.; Paes, M. F.; Herlinger, A.; Lyra Junior, P. C. M.; Silva, Iv; Rangel, Lba . , 2012, Chicago. Proceedings Of The 103rd Annual Meeting Of The American Association For Cancer Research, 2012. V. 1.

Herlinger, A.; Valadao, I.; Daltoe, R.; Madeira, K.; Allochio, Jf; Rezende, L. C. D.; Cerri, M. F.; Teixeira, S.; Lyra Junior, P. C. M. 2012, Rio De Janeiro. Poster Abstracts, 2012. V. 1. P. 95-95.

Cerri, M. F.; Guimaraes, I.; Rezende, L. C. D.; Paes, M. F.; Silva, D.; Lyra Junior, P. C. M.; Tommasi, B. O.; Silva, Iv; Rangel, Lba . , 2011, Rio De Janeiro. Anais Da XXVI Reunião Anual Da Fesbe, 2011. V. 1.

Cerri, M. F.; Rezende, L. C. D.; Lyra Junior, P. C. M.; Paes, M. F.; Silva, D.; Sirtoli, G. M.; Tommasi, B. O.; Silva, Iv; Rangel, L. B. A. 2010, Guarujá. 56 Congresso Brasileiro De Genética, 2010. V. 56. P. 31-31.

Cerri, M. F.; Rezende, L. C. D.; Paes, M. F.; Lyra Junior, P. C. M.; Silva, D.; Sirtoli, G. M.; Tommasi, B. O.; Silva, Iv; Rangel, Lba . , 2010, Guarujá. 56 Congresso Brasileiro De Genética, 2010. V. 56. P. 32-32.

Cerri, M. F.; Rezende, L. C. D.; Paes, M. F.; Silva, D.; Goncalves, N. T. L. P.; Lyra Junior, P. C. M.; Tommasi, B. O.; Silva, Iv; Rangel, L. B. A. 2010, Vitória. Iv Congresso De Ciências Da Saúde, 2010. V. 4. P. 125-126.

IV. OTHER SKILLS

Genomics Data Analysis – Ongoing – HarvardX: XSeries.

Statistical Inference and Modeling for High-throughput Experiments - Ongoing - HarvardX.

High-performance Computing for Reproducible Genomics – Ongoing – HarvardX: PH525.3x.

https://www.freecodecamp.org/paulocilasjr - Ongoing.

CS50's Web Programming with Python and JavaScript - 2020 - HarvardX.

Statistics and R - 2019 - HarvardX.

Introduction to Computer Science and Programming Using Python – 2018 – MITx:6.00.1x.

Using Python for Research – 2018 – HarvardX:PH526x.

Introduction to Computing Using Python – 2017 – Georgia Institute of Technology.

CS50's Introduction to Computer Science - 2017 - HarvardX.

MicroRNAs and Cancer: Updates – 2010 – Sociedade Brasileira de Genética.

Cell Culture of Normal cells and Tumor cells: Methods and applications – 2009 – Federeção das Sociedades de Biologia Experimental.

Homeopathic manipulation for deontological and veterinary usage – 2008 – EMESCAM.

Injection Course – 2008 – EMESCAM.

V. TEACHING EXPERIENCE

Pharmaceutical assistance and attention.

Pharmacodynamics I and II.

Pharmacotechnic I and II

Biochemistry I

Quality control in clinical analyzes

Pharmacodynamic I and II

Pharmacotechnic II

Biosafety